Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis
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Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis
BACKGROUND Pre-eclampsia is thought to have an important genetic component. Recently, pre-eclampsia has been associated in some studies with carriage of a common eNOS gene Glu298Asp polymorphism, a variant that leads to the replacement of glutamic acid by aspartic acid at codon 298. METHOD Healthy women with singleton pregnancies were recruited from 7 district general hospitals in London, UK....
متن کاملEndothelial Nitric Oxide Synthase Gene Polymorphism (Glu298Asp) and Development of Pre-eclampsia: a case-control study and a meta-analysis. Authors: Yu CK
Background Pre-eclampsia is thought to have an important genetic component. Recently, pre-eclampsia has been associated in some studies with carriage of a common eNOS gene Glu298Asp polymorphism, a variant that leads to the replacement of glutamic acid by aspartic acid at codon 298. Method Healthy women with singleton pregnancies were recruited from 7 district general hospitals in London, UK. W...
متن کاملAuthor's response to reviews Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of Title: pre-eclampsia: a nested case-control study and a meta-analysis Authors:
Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of Title: pre-eclampsia: a nested case-control study and a meta-analysis
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Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملAssociation between the endothelial nitric oxide synthase gene Glu298Asp polymorphism and coronary heart disease: a meta‑analysis of 39 case‑control studies.
Numerous studies have indicated that the human endothelial nitric oxide synthase (eNOS) gene Glu298Asp polymorphism is associated with coronary heart disease (CHD) susceptibility, however, their conclusions are inconsistent. The present meta‑analysis aimed to evaluate the precise result by searching the PubMed database and using 39 case‑control studies comprising 7489 cases and 7051 controls.Ea...
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ژورنال
عنوان ژورنال: BMC Pregnancy and Childbirth
سال: 2006
ISSN: 1471-2393
DOI: 10.1186/1471-2393-6-7